Serial Free Bisphenol A and Bisphenol A Glucuronide Concentrations in Neonates
نویسندگان
چکیده
منابع مشابه
Serial Free Bisphenol A and Bisphenol A Glucuronide Concentrations in Neonates.
OBJECTIVE To determine the balance of metabolism of free bisphenol A (BPA) to the inactive conjugate, BPA glucuronide (BPAG), in neonates. STUDY DESIGN Free BPA and BPAG concentrations were measured in 78 urine samples collected between December 2012 and August 2013 from a cohort of 44 healthy full term (≥ 37 weeks' gestation) neonates at 2 intervals (3-6 days and 7-27 days of age). A questio...
متن کاملBisphenol A glucuronide/sulfate diconjugate in perfused liver of rats
In isolated hepatocytes, the environmental estrogen bisphenol A (BPA) is metabolized into a mono-glucuronide and a glucuronide/sulfate diconjugate. Little is known about the fate of the diconjugate in the liver. The present study focused on the metabolism and dispostion of BPA diconjugate in the liver using a perfusion method. In Sprague-Dawley rats, BPA (15,150 or 1,500 nmol) was applied into ...
متن کاملQuantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry.
Bisphenol A (BPA) is a weak estrogen. Pharmacokinetic studies of BPA have demonstrated a rapid and extensive metabolism of BPA to the nonestrogenic BPA-monoglucuronide (BPA-gluc). Some investigators have reported that BPA was found at parts per billion concentrations in the tissues or urine of humans without known exposure to BPA. This work developed a rapid and sensitive method for the determi...
متن کاملComparison of Conjugative Activity, Conversion of Bisphenol A to Bisphenol A Glucuronide, in Fetal and Mature Male Rat
We showed previously that orally administered bisphenol A (BPA) easily crosses the placental barrier and enters the fetus. However, BPA glucuronide transport and metabolism in the fetus was not studied. We examined the transport of orally administered BPA and BPA glucuronide into mature rat testis and fetus of pregnant rats. After administration of an oral dose of 10 mg BPA per kg body weight t...
متن کاملHuman and rat ABC transporter efflux of bisphenol a and bisphenol a glucuronide: interspecies comparison and implications for pharmacokinetic assessment.
Significant interspecies differences exist between human and rodent with respect to absorption, distribution, and excretion of bisphenol A (BPA) and its primary metabolite, BPA-glucuronide (BPA-G). ATP-Binding Cassette (ABC) transporter enzymes play important roles in these physiological processes, and their enzyme localization (apical vs. basolateral) in the plasma membrane allows for differen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Pediatrics
سال: 2015
ISSN: 0022-3476
DOI: 10.1016/j.jpeds.2015.03.036